In the last three decades, HIV/AIDS, a disease first reported in humans in 1981 in the United States, has spread across all continents and claimed millions of lives. It has posed one of the biggest public health threats known to man, and changed the course of history. HIV proved to be a formidable enemy, resisting drugs quickly and evading potential vaccines. But the story of HIV/AIDS is also a tale of triumph of human ingenuity, determination and commitment. Infection with HIV was once considered a death sentence.